Sentiment-Signal
16,8
Stark Bearisch
Composite Score (0–100)
Insider (25%)
0
Keine Insider-Käufe
Institutionell (22,5%)
16.1
Keine neuen Positionen
Aktivist (12,5%)
0
Kein 13D/13G
Risikofreier Zins (T-Bills): 3,70% (Stand: 31.03.2026)
Score-Verlauf (90 Tage)
Stammdaten
Bicycle Therapeutics plc, a clinical-stage biopharmaceutical company, develops a class of medicines for diseases that are underserved by existing therapeutics. Its lead product candidate is BT1718, a bicycle toxin conjugate (BTC), which is in Phase I/IIa clinical trials targeting tumors that express Membrane Type 1 matrix metalloprotease. The company's oncology product candidates also comprise BT5528, a BTC that is in a Phase I/II clinical trial targeting EphA2; and BT8009, which is in Phase I/II clinical trial targeting Nectin-4. In addition, it is developing THR-149, a plasma kallikrein inhibitor that completed Phase II clinical trials for the treatment of diabetic macular edema; BT7480, a Bicycle tumor-targeted immune cell agonist (TICA) targeting Nectin-4 and agonizing; BT7455, an EphA2/CD137 Bicycle TICA, which is in preclinical studies; and BT1718, a BTC that target tumors, that is in Phase I/IIa clinical trial that express Membrane Type 1 matrix metalloproteinase. Further, the company collaborates with biopharmaceutical companies and organizations to develop programs in therapeutic areas, such as anti-infective, cardiovascular, ophthalmology, and respiratory indications. It has a clinical trial and license agreement with the Cancer Research Technology Limited and Cancer Research UK; research collaboration agreements with AstraZeneca, Sanofi, Oxurion, and the Dementia Discovery Fund; and discovery collaboration and license agreement with Genentech for the discovery and development of Bicycle peptides for multiple immuno-oncology targets. Bicycle Therapeutics plc was incorporated in 2009 and is headquartered in Cambridge, the United Kingdom.
Unternehmen & Branche
| Name | BICYCLE THERAPEUTICS PLC |
|---|---|
| Ticker | BCYC |
| CIK | 0001761612 |
| Boerse | US |
| Sektor | Healthcare |
| Industrie | Biotechnology |
| SIC | 2834 · Pharmaceutical Preparations |
Wertpapier & Kennzahlen
| CUSIP | 088786108 |
|---|---|
| ISIN | US0887861088 |
| Typ | ADR |
| Marktkapitalisierung | 367,4 Mio. USD |
| Beta | 1,65 |
| Dividendenrendite | 0,00 % |
Externe Quellen: SEC EDGAR » · FMP-Profil » · Yahoo Finance »
Finanzkennzahlen (SEC XBRL)
| Periode | Filing | Umsatz | Nettoergebnis | EPS | Aktiva | Eigenkapital |
|---|---|---|---|---|---|---|
| 2025-12-31 | 10-K | 72,586,000 | -218,960,000 | -3.16 | 717,597,000 | 609,977,000 |
| 2025-09-30 | 10-Q | 11,734,000 | -59,100,000 | -0.85 | 763,954,000 | 618,479,000 |
| 2025-06-30 | 10-Q | 2,920,000 | -78,952,000 | -1.14 | 832,184,000 | 668,915,000 |
| 2025-03-31 | 10-Q | 9,977,000 | -60,754,000 | -0.88 | 883,894,000 | 740,333,000 |
| 2024-12-31 | 10-K | 35,275,000 | -169,031,000 | -2.90 | 956,868,000 | 793,060,000 |
| 2024-09-30 | 10-Q | 2,676,000 | -50,802,000 | -0.74 | 996,746,000 | 831,032,000 |
| 2024-06-30 | 10-Q | 9,361,000 | -39,812,000 | -0.77 | 1,057,355,000 | 873,813,000 |
| 2024-03-31 | 10-Q | 19,530,000 | -26,563,000 | -0.62 | 547,143,000 | 356,048,000 |
| 2023-12-31 | 10-K | 26,976,000 | -180,664,000 | -5.08 | 595,344,000 | 370,932,000 |
| 2023-09-30 | 10-Q | 0 | -49,898,000 | -1.26 | 638,683,000 | 416,022,000 |
| 2023-06-30 | 10-Q | 0 | -42,603,000 | -1.41 | 454,170,000 | 220,097,000 |
| 2023-03-31 | 10-Q | 4,896,000 | -39,064,000 | -1.30 | 428,801,000 | 243,163,000 |
| 2022-12-31 | 10-K | 14,463,000 | -112,717,000 | -3.80 | 410,609,000 | 270,783,000 |
| 2022-09-30 | 10-Q | 3,040,000 | -28,347,000 | -0.96 | 417,148,000 | 289,474,000 |
| 2022-06-30 | 10-Q | 4,378,000 | -26,828,000 | -0.90 | 445,482,000 | 311,392,000 |
| 2022-03-31 | 10-Q | 3,860,000 | -27,564,000 | -0.93 | 459,563,000 | 330,258,000 |
| 2021-12-31 | 10-K | 11,697,000 | -66,819,000 | -2.67 | 479,792,000 | 346,254,000 |
| 2021-09-30 | 10-Q | 4,333,000 | -14,678,000 | -0.59 | 281,333,000 | 170,823,000 |
| 2021-06-30 | 10-Q | 1,785,000 | -17,913,000 | -0.74 | 226,048,000 | 142,050,000 |
| 2021-03-31 | 10-Q | 1,808,000 | -16,191,000 | -0.73 | 223,842,000 | 142,091,000 |
Fondsaktivität (Vorquartalsvergleich)
| Fonds | Aktuell (Stk) | Vorquartal (Stk) | Veränderung (Stk) | Wert (USD) | Status | Δ | Trend |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 10,885,357 | 0 | 10,885,357 | 77,068,328 | Neu | +100,0% | |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 3,016,026 | 0 | 3,016,026 | 21,353,464 | Neu | +100,0% | |
| Siren, L.L.C. | 2,012,752 | 0 | 2,012,752 | 14,250,284 | Neu | +100,0% | |
| Long Focus Capital Management, LLC | 1,633,091 | 0 | 1,633,091 | 11,562,284 | Neu | +100,0% | |
| Candriam S.C.A. | 1,192,279 | 0 | 1,192,279 | 8,441,695 | Neu | +100,0% | |
| PRINCIPAL FINANCIAL GROUP INC | 1,148,272 | 0 | 1,148,272 | 8,129,766 | Neu | +100,0% | |
| RENAISSANCE TECHNOLOGIES LLC | 566,600 | 0 | 566,600 | 4,011,528 | Neu | +100,0% | |
| MORGAN STANLEY | 465,222 | 0 | 465,222 | 3,293,773 | Neu | +100,0% | |
| Birchview Capital, LP | 462,700 | 0 | 462,700 | 3,275,916 | Neu | +100,0% | |
| BlackRock, Inc. | 332,889 | 0 | 332,889 | 2,356,854 | Neu | +100,0% | |
| MILLENNIUM MANAGEMENT LLC | 326,626 | 0 | 326,626 | 2,312,512 | Neu | +100,0% | |
| CITADEL ADVISORS LLC | 313,083 | 0 | 313,083 | 2,216,627 | Neu | +100,0% | |
| Jefferies Financial Group Inc. | 297,247 | 0 | 297,247 | 2,104,509 | Neu | +100,0% | |
| MOORE CAPITAL MANAGEMENT, LP | 275,000 | 0 | 275,000 | 1,947,000 | Neu | +100,0% | |
| Palo Alto Investors LP | 221,071 | 0 | 221,071 | 1,565,183 | Neu | +100,0% | |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 202,423 | 0 | 202,423 | 1,433,155 | Neu | +100,0% | |
| PINNACLE ASSOCIATES LTD | 190,480 | 0 | 190,480 | 1,348,598 | Neu | +100,0% | |
| PLATINUM INVESTMENT MANAGEMENT LTD | 184,603 | 0 | 184,603 | 1,306,989 | Neu | +100,0% | |
| Eversept Partners, LP | 178,915 | 0 | 178,915 | 1,266,718 | Neu | +100,0% | |
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | 134,689 | 0 | 134,689 | 953,600 | Neu | +100,0% | |
| TWO SIGMA INVESTMENTS, LP | 132,032 | 0 | 132,032 | 934,787 | Neu | +100,0% | |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 127,863 | 0 | 127,863 | 869,468 | Neu | +100,0% | |
| Walleye Capital LLC | 111,759 | 0 | 111,759 | 791,254 | Neu | +100,0% | |
| BANK OF AMERICA CORP /DE/ | 96,401 | 0 | 96,401 | 682,519 | Neu | +100,0% | |
| MONIMUS CAPITAL MANAGEMENT, LP | 93,840 | 0 | 93,840 | 664,387 | Neu | +100,0% | |
| Marex Group plc | 78,406 | 0 | 78,406 | 555,114 | Neu | +100,0% | |
| JANE STREET GROUP, LLC | 77,990 | 0 | 77,990 | 552,169 | Neu | +100,0% | |
| STATE STREET CORP | 70,178 | 0 | 70,178 | 496,860 | Neu | +100,0% | |
| DAFNA Capital Management LLC | 64,492 | 0 | 64,492 | 456,603 | Neu | +100,0% | |
| State of Tennessee, Department of Treasury | 61,153 | 0 | 61,153 | 392,603 | Neu | +100,0% | |
| SEI INVESTMENTS CO | 49,056 | 0 | 49,056 | 347,316 | Neu | +100,0% | |
| XTX Topco Ltd | 47,674 | 0 | 47,674 | 337,532 | Neu | +100,0% | |
| Quadrature Capital Ltd | 46,728 | 0 | 46,728 | 330,834 | Neu | +100,0% | |
| Man Group plc | 42,860 | 0 | 42,860 | 303,449 | Neu | +100,0% | |
| MARSHALL WACE, LLP | 38,795 | 0 | 38,795 | 274,669 | Neu | +100,0% | |
| Virtus Investment Advisers, LLC | 35,709 | 0 | 35,709 | 252,820 | Neu | +100,0% | |
| SIMPLEX TRADING, LLC | 31,786 | 0 | 31,786 | 225,044 | Neu | +100,0% | |
| UBS Group AG | 25,676 | 0 | 25,676 | 181,786 | Neu | +100,0% | |
| GEODE CAPITAL MANAGEMENT, LLC | 25,129 | 0 | 25,129 | 177,913 | Neu | +100,0% | |
| GOLDMAN SACHS GROUP INC | 24,732 | 0 | 24,732 | 175,103 | Neu | +100,0% | |
| Engineers Gate Manager LP | 24,047 | 0 | 24,047 | 170,253 | Neu | +100,0% | |
| D. E. Shaw & Co., Inc. | 21,548 | 0 | 21,548 | 152,560 | Neu | +100,0% | |
| State of New Jersey Common Pension Fund D | 20,105 | 0 | 20,105 | 142,343 | Neu | +100,0% | |
| FOX RUN MANAGEMENT, L.L.C. | 19,771 | 0 | 19,771 | 139,979 | Neu | +100,0% | |
| Aquatic Capital Management LLC | 18,817 | 0 | 18,817 | 133,224 | Neu | +100,0% | |
| JPMORGAN CHASE & CO | 18,355 | 0 | 18,355 | 129,953 | Neu | +100,0% | |
| PORTLAND INVESTMENT COUNSEL INC. | 15,000 | 0 | 15,000 | 106,200 | Neu | +100,0% | |
| Federation des caisses Desjardins du Quebec | 14,302 | 0 | 14,302 | 101,131 | Neu | +100,0% | |
| HORIZON KINETICS ASSET MANAGEMENT LLC | 13,792 | 0 | 13,792 | 97,647 | Neu | +100,0% | |
| Forefront Analytics, LLC | 13,371 | 0 | 13,371 | 94,667 | Neu | +100,0% |
Insider-Transaktionen (12 Monate)
| Datum | Insider | Rolle | Typ | Stückzahl | Kurs | Wert (USD) | Δ | Trend |
|---|---|---|---|---|---|---|---|---|
| 2026-04-06 | Hannay Michael Charles Ferguson | Officer, CHIEF PROD & SUPPLY CHAIN OFF | Open Market Sale | -251 | 5.05 | -1,267.55 | -10,3% | |
| 2026-04-06 | Skynner Michael | Officer, CHIEF SCIENTIFIC OFFICER | Open Market Sale | -525 | 5.05 | -2,651.25 | -21,6% | |
| 2026-04-06 | Lee Kevin | Director, Officer, CHIEF EXECUTIVE OFFICER | Open Market Sale | -1,716 | 5.05 | -8,665.80 | -70,7% | |
| 2026-04-06 | Perry Jennifer Scott | Officer, Chief Operating Officer | Open Market Sale | -333 | 5.04 | -1,678.32 | -13,7% | |
| 2026-04-06 | Perry Jennifer Scott | Officer, Chief Operating Officer | Open Market Sale | -37 | 5.05 | -186.85 | -1,5% | |
| 2026-04-06 | Thompson Travis Alvin | Officer, Chief Financial Officer | Open Market Sale | -102 | 5.05 | -515.10 | -4,2% | |
| 2026-04-02 | Thompson Travis Alvin | Officer, Chief Financial Officer | Open Market Sale | -799 | 4.91 | -3,923.09 | -32,0% | |
| 2026-04-02 | Skynner Michael | Officer, CHIEF SCIENTIFIC OFFICER | Open Market Sale | -1,879 | 4.91 | -9,225.89 | -75,3% | |
| 2026-04-02 | Perry Jennifer Scott | Officer, Chief Operating Officer | Open Market Sale | -1,038 | 4.91 | -5,096.58 | -41,6% | |
| 2026-04-02 | Lee Kevin | Director, Officer, CHIEF EXECUTIVE OFFICER | Open Market Sale | -5,967 | 4.91 | -29,297.97 | -239,1% | |
| 2026-04-02 | Hannay Michael Charles Ferguson | Officer, CHIEF PROD & SUPPLY CHAIN OFF | Open Market Sale | -1,521 | 4.91 | -7,468.11 | -60,9% | |
| 2026-01-05 | Thompson Travis Alvin | Officer, CHIEF ACCOUNTING OFFICER | Open Market Sale | -1,115 | 6.45 | -7,191.75 | -58,7% | |
| 2026-01-05 | Milnes Alistair | Officer, CHIEF OPERATING OFFICER | Open Market Sale | -3,416 | 6.46 | -22,067.36 | -180,1% | |
| 2026-01-05 | Young Alethia | Officer, Chief Financial Officer | Open Market Sale | -1,878 | 6.54 | -12,282.12 | -100,2% | |
| 2026-01-05 | Young Alethia | Officer, Chief Financial Officer | Open Market Sale | -2,456 | 6.45 | -15,841.20 | -129,3% | |
| 2026-01-05 | Lee Kevin | Director, Officer, CHIEF EXECUTIVE OFFICER | Open Market Sale | -10,989 | 6.46 | -70,988.94 | -579,3% | |
| 2026-01-05 | Skynner Michael | Officer, CHIEF TECHNOLOGY OFFICER | Open Market Sale | -3,266 | 6.46 | -21,098.36 | -172,2% | |
| 2026-01-05 | Hannay Michael Charles Ferguson | Officer, CHIEF PROD & SUPPLY CHAIN OFF | Open Market Sale | -2,367 | 6.45 | -15,267.15 | -124,6% | |
| 2026-01-02 | Lee Kevin | Director, Officer, CHIEF EXECUTIVE OFFICER | Open Market Sale | -10,325 | 6.80 | -70,210.00 | -572,9% | |
| 2026-01-02 | Skynner Michael | Officer, CHIEF TECHNOLOGY OFFICER | Open Market Sale | -3,045 | 6.80 | -20,706.00 | -169,0% | |
| 2026-01-02 | Milnes Alistair | Officer, CHIEF OPERATING OFFICER | Open Market Sale | -3,244 | 6.80 | -22,059.20 | -180,0% | |
| 2026-01-02 | Young Alethia | Officer, Chief Financial Officer | Open Market Sale | -3,289 | 6.80 | -22,365.20 | -182,5% | |
| 2026-01-02 | Thompson Travis Alvin | Officer, CHIEF ACCOUNTING OFFICER | Open Market Sale | -1,317 | 6.80 | -8,955.60 | -73,1% | |
| 2026-01-02 | Hannay Michael Charles Ferguson | Officer, CHIEF PROD & SUPPLY CHAIN OFF | Open Market Sale | -2,827 | 6.80 | -19,223.60 | -156,9% | |
| 2025-10-03 | Lee Kevin | Director, Officer, CHIEF EXECUTIVE OFFICER | Open Market Sale | -3,231 | 8.41 | -27,172.71 | -221,7% | |
| 2025-10-03 | Hannay Michael Charles Ferguson | Officer, CHIEF PROD & SUPPLY CHAIN OFF | Open Market Sale | -250 | 8.41 | -2,102.50 | -17,2% | |
| 2025-10-03 | Thompson Travis Alvin | Officer, CHIEF ACCOUNTING OFFICER | Open Market Sale | -103 | 8.41 | -866.23 | -7,1% | |
| 2025-10-03 | Skynner Michael | Officer, CHIEF TECHNOLOGY OFFICER | Open Market Sale | -978 | 8.41 | -8,224.98 | -67,1% | |
| 2025-10-03 | Milnes Alistair | Officer, CHIEF OPERATING OFFICER | Open Market Sale | -978 | 8.41 | -8,224.98 | -67,1% | |
| 2025-10-02 | Skynner Michael | Officer, CHIEF TECHNOLOGY OFFICER | Open Market Sale | -824 | 8.40 | -6,921.60 | -56,5% | |
| 2025-10-02 | Hannay Michael Charles Ferguson | Officer, CHIEF PROD & SUPPLY CHAIN OFF | Open Market Sale | -473 | 8.40 | -3,973.20 | -32,4% | |
| 2025-10-02 | Young Alethia | Officer, Chief Financial Officer | Open Market Sale | -265 | 8.61 | -2,280.33 | -18,6% | |
| 2025-10-02 | Young Alethia | Officer, Chief Financial Officer | Open Market Sale | -217 | 8.40 | -1,822.80 | -14,9% | |
| 2025-10-02 | Milnes Alistair | Officer, CHIEF OPERATING OFFICER | Open Market Sale | -1,147 | 8.40 | -9,634.80 | -78,6% | |
| 2025-10-02 | Swanton Robert Charles | Director | Open Market Sale | -102 | 8.55 | -872.10 | -7,1% | |
| 2025-10-02 | Thompson Travis Alvin | Officer, CHIEF ACCOUNTING OFFICER | Open Market Sale | -221 | 8.40 | -1,856.40 | -15,1% | |
| 2025-10-02 | Lee Kevin | Director, Officer, CHIEF EXECUTIVE OFFICER | Open Market Sale | -2,263 | 8.40 | -19,009.20 | -155,1% | |
| 2025-07-03 | Hannay Michael Charles Ferguson | Officer, CHIEF PROD & SUPPLY CHAIN OFF | Open Market Sale | -248 | 7.44 | -1,845.12 | -15,1% | |
| 2025-07-03 | Skynner Michael | Officer, CHIEF TECHNOLOGY OFFICER | Open Market Sale | -966 | 7.44 | -7,187.04 | -58,6% | |
| 2025-07-03 | Lee Kevin | Director, Officer, CHIEF EXECUTIVE OFFICER | Open Market Sale | -3,193 | 7.44 | -23,755.92 | -193,8% | |
| 2025-07-03 | Thompson Travis Alvin | Officer, CHIEF ACCOUNTING OFFICER | Open Market Sale | -100 | 7.44 | -744.00 | -6,1% | |
| 2025-07-02 | Hannay Michael Charles Ferguson | Officer, CHIEF PROD & SUPPLY CHAIN OFF | Open Market Sale | -474 | 7.09 | -3,360.66 | -27,4% | |
| 2025-07-02 | Thompson Travis Alvin | Officer, CHIEF ACCOUNTING OFFICER | Open Market Sale | -206 | 7.09 | -1,460.54 | -11,9% | |
| 2025-07-02 | Skynner Michael | Officer, CHIEF TECHNOLOGY OFFICER | Open Market Sale | -825 | 7.09 | -5,849.25 | -47,7% | |
| 2025-07-02 | Lee Kevin | Director, Officer, CHIEF EXECUTIVE OFFICER | Open Market Sale | -2,268 | 7.09 | -16,080.12 | -131,2% |
Fail-to-Deliver (6 Monate)
| Datum | FTD-Menge | Kurs | Wert (USD) |
|---|---|---|---|
| 2026-02-27 | 38.683 | 5,64 | 218.172 |
| 2026-02-26 | 39.008 | 5,73 | 223.516 |
Top-Fondshalter
Hinweis: Keine aktuelleren Daten zu dieser Aktie verfuegbar. Stand der gezeigten 13F-Holdings: 31.12.2025. Letztes global veroeffentlichtes 13F-Quartal: 31.03.2026.
| Fonds | Anteile | Wert (USD) | Anteil (%) |
|---|---|---|---|
| BAKER BROS. ADVISORS LP | 10,885,357 | 77,068,328 | 42.46 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 3,016,026 | 21,353,464 | 11.77 |
| Siren, L.L.C. | 2,012,752 | 14,250,284 | 7.85 |
| Long Focus Capital Management, LLC | 1,633,091 | 11,562,284 | 6.37 |
| Candriam S.C.A. | 1,192,279 | 8,441,695 | 4.65 |
| PRINCIPAL FINANCIAL GROUP INC | 1,148,272 | 8,129,766 | 4.48 |
| RENAISSANCE TECHNOLOGIES LLC | 566,600 | 4,011,528 | 2.21 |
| MORGAN STANLEY | 465,222 | 3,293,773 | 1.81 |
| Birchview Capital, LP | 462,700 | 3,275,916 | 1.80 |
| BlackRock, Inc. | 332,889 | 2,356,854 | 1.30 |
| MILLENNIUM MANAGEMENT LLC | 326,626 | 2,312,512 | 1.27 |
| CITADEL ADVISORS LLC | 313,083 | 2,216,627 | 1.22 |
| Jefferies Financial Group Inc. | 297,247 | 2,104,509 | 1.16 |
| MOORE CAPITAL MANAGEMENT, LP | 275,000 | 1,947,000 | 1.07 |
| Palo Alto Investors LP | 221,071 | 1,565,183 | 0.86 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 202,423 | 1,433,155 | 0.79 |
| PINNACLE ASSOCIATES LTD | 190,480 | 1,348,598 | 0.74 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 184,603 | 1,306,989 | 0.72 |
| Eversept Partners, LP | 178,915 | 1,266,718 | 0.70 |
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | 134,689 | 953,600 | 0.53 |